Osmotic diuresis is increased urination due to the presence of certain substances in the fluid filtered by the kidneys. This fluid eventually becomes urine. The process of osmosis created by these substances causes additional water to come into the urine, increasing its amount.
Causes
Osmotic diuresis can be caused by:
- High blood sugar (glucose)
- Use of certain medicines, such as Mannitol
References
Kamel KS, Halperin ML. Interpretation of electrolyte and acid-base parameters in blood and urine. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 24.
Pfennig CL, Slovis CM. Electrolyte disorders. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 114.
Review Date 7/23/2024
Updated by: Linda J. Vorvick, MD, Clinical Professor, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.