June Release - 06/05/2017
This release of RxNorm is consistent with the 2017AA UMLS Metathesaurus release. For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm technical documentation.
Sources
The following sources have been updated since the previous RxNorm release:
| Source Name | SAB | Version |
|---|---|---|
| Vaccines Administered | CVX | CVX_2017_05_03 |
| DrugBank | DRUGBANK | DRUGBANK5.0_2017_04_28 |
| Gold Standard Drug Database | GS | GS_2017_05_01 |
| Medi-Span Master Drug Data Base | MDDB | MDDB_2017_05_03 |
| Multum MediSource Lexicon | MMSL | MMSL_2017_05_01 |
| Micromedex RED BOOK | MMX | MMX_2017_05_01 |
| FDA Structured Product Labels | MTHSPL | MTHSPL_2017_05_26 |
| FDB MedKnowledge (formerly NDDF Plus) | NDDF | NDDF_2017_05_03 |
| Veterans Health Administration National Drug File - Reference Terminology | NDFRT | NDFRT_2017_06_05 |
| NDFRT FDASPL relationships | NDFRT_FDASPL | NDFRT_FDASPL_2017_06_05 |
| NDFRT FMTSME relationships | NDFRT_FMTSME | NDFRT_FMTSME_2017_06_05 |
| Veterans Health Administration National Drug File | VANDF | VANDF_2017_04_24 |
The following sources have not been updated in this release:
| Source Name | SAB | Version |
|---|---|---|
| Anatomical Therapeutic Chemical Classification System | ATC | ATC_2017 |
| CMS Formulary Reference File | MTHCMSFRF | MTHCMSFRF_2014 |
| Medical Subject Headings (MeSH) | MSH | MSH2017_2017_02_14 |
| US Edition of SNOMED CT (drug information) | SNOMEDCT_US | SNOMEDCT_US_2017_01_31 |
Data Changes
Data Error
Six RXCUIs (1088899, 1562, 219009, 236117, 314522, 582031) were incorrectly mapped to RXCUI 350141 and appeared in the June RXNCUICHANGES.RRF file. This error will be corrected in the July monthly release. The six RXCUIs that were incorrectly mapped will be archived and will appear in the RXNATOMARCHIVE.RRF file for the monthly release in July.
Qualitative Distinction
Please see the technical documentation for an explanation of Qualitative Distinctions (QDs), which were first released in the August monthly release.
Here are the new concepts with QDs in the June release:
| RXCUI | TTY | String |
|---|---|---|
| 1922877 | SBD | Preservative-Free Timolol 2.5 MG/ML Ophthalmic Solution [Timoptic] |
| 1922895 | SBD | Preservative-Free Timolol 5 MG/ML Ophthalmic Solution [Timoptic] |
| 1922784 | SBD | Preservative-Free dorzolamide 20 MG/ML / Timolol 5 MG/ML Ophthalmic Solution [Cosopt] |
| 1922876 | SCD | Preservative-Free Timolol 2.5 MG/ML Ophthalmic Solution |
| 1922894 | SCD | Preservative-Free Timolol 5 MG/ML Ophthalmic Solution |
| 1922783 | SCD | Preservative-Free dorzolamide 20 MG/ML / Timolol 5 MG/ML Ophthalmic Solution |
| 1922721 | SBD | Atrial Fibrillation Sotalol Hydrochloride 120 MG Oral Tablet [Betapace] |
| 1922764 | SBD | Atrial Fibrillation Sotalol Hydrochloride 160 MG Oral Tablet [Betapace] |
| 1922766 | SBD | Atrial Fibrillation Sotalol Hydrochloride 80 MG Oral Tablet [Betapace] |
| 1922720 | SCD | Atrial Fibrillation Sotalol Hydrochloride 120 MG Oral Tablet |
| 1922763 | SCD | Atrial Fibrillation Sotalol Hydrochloride 160 MG Oral Tablet |
| 1922765 | SCD | Atrial Fibrillation Sotalol Hydrochloride 80 MG Oral Tablet |
For each SCD or SBD with a QD, there is an associated attribute in RXNSAT with the attribute name (ATN) of 'RXN_QUALITATIVE_DISTINCTION'. The June release contains the following new attributes to match the QD strings found in the SCD and SBD normalized names:
- Preservative-Free
- Atrial Fibrillation
New RXCUI for Same Normal Form when Concept Meaning Changes
RxNorm now creates a new concept unique identifier (RXCUI) for an existing RxNorm normalized name to reflect a change in the drug product represented. In the past, RxNorm minimized changes to RXCUIs; however, beginning with the June 2017 release, RXCUIs can change for an existing RxNorm normalized name. The concepts most impacted will be the concepts that group drugs together that need to have separate RXCUIs. When the original concept is split to represent distinct drugs with unique RXCUIs, the original RXCUI will be archived and replaced with a new RXCUI if the original normalized name is retained.
For example, in the May 2017 release, RXCUI 904603 with SBD = Sotalol Hydrochloride 80 MG Oral Tablet [Betapace], represented two separate drugs: Betapace 80 MG Oral Tablet -OR- Betapace AF 80 MG Oral Tablet.
The May 2017 RxNorm Release included the following concept:
| RXCUI | TTY | String |
|---|---|---|
| 904603 | SBD | Sotalol Hydrochloride 80 MG Oral Tablet [Betapace] |
In the June 2017 release, the RxNorm editing team split RXCUI 904603, creating a new concept RXCUI 1923427 with SBD = Atrial Fibrillation Sotalol Hydrochloride 80 MG Oral Tablet [Betapace]), leaving the original concept to represent only one drug, Betapace 80 MG Oral Tablet.
The June 2017 RxNorm Release included the following two concepts with new RXCUIs:
| RXCUI | TTY | String |
|---|---|---|
| 1923427 | SBD | Sotalol Hydrochloride 80 MG Oral Tablet [Betapace] |
| 1922766 | SBD | Atrial Fibrillation Sotalol Hydrochloride 80 MG Oral Tablet [Betapace] |
To reflect the change in meaning to RXCUI 904603 in the June release, the original RXCUI 904603 was archived and a new RxCUI 1923427 was created while keeping the original normalized name.
The June 2017 release includes new RXCUIs for the following active concepts:
| RXCUI1 (old) | RXCUI2 (new) | TTY | STR |
|---|---|---|---|
| 670640 | 1923429 | SBD | Timolol 2.5 MG/ML Ophthalmic Solution [Timoptic] |
| 670646 | 1923431 | SBD | Timolol 5 MG/ML Ophthalmic Solution [Timoptic] |
| 198283 | 1923428 | SCD | Timolol 2.5 MG/ML Ophthalmic Solution |
| 313409 | 1923430 | SCD | Timolol 5 MG/ML Ophthalmic Solution |
| 213280 | 1923433 | SBD | dorzolamide 20 MG/ML / Timolol 5 MG/ML Ophthalmic Solution [Cosopt] |
| 313954 | 1923432 | SCD | dorzolamide 20 MG/ML / Timolol 5 MG/ML Ophthalmic Solution |
| 904569 | 1923423 | SBD | Sotalol Hydrochloride 160 MG Oral Tablet [Betapace] |
| 904581 | 1923425 | SBD | Sotalol Hydrochloride 120 MG Oral Tablet [Betapace] |
| 904603 | 1923427 | SBD | Sotalol Hydrochloride 80 MG Oral Tablet [Betapace] |
| 904579 | 1923424 | SCD | Sotalol Hydrochloride 160 MG Oral Tablet |
| 904567 | 1923422 | SCD | Sotalol Hydrochloride 120 MG Oral Tablet |
| 904601 | 1923426 | SCD | Sotalol Hydrochloride 80 MG Oral Tablet |
The old and new RXCUIs can be found in the RXNCUI file along with the cardinality indicating the number of RXCUIs in which the original RXCUI was moved or split.
Data Counts
| Term Type or Attribute | Number |
|---|---|
| Active GPCKs | 375 |
| Active BPCKs | 444 |
| Active SCDs | 18611 |
| Active SBDs | 10466 |
| Active RXNORM MINs | 3941 |
| Active RXNORM INs | 11392 |
| Active RXNORM PINs | 2669 |
| Active RXNORM BNs | 6115 |
| Active RXNORM DFs | 116 |
| Obsolete GPCKs | 157 |
| Obsolete BPCKs | 132 |
| Obsolete SCDs | 16417 |
| Obsolete SBDs | 10404 |
| Obsolete RXNORM MINs | 0 |
| Obsolete RXNORM INs | 0 |
| Obsolete RXNORM PINs | 0 |
| Obsolete RXNORM BNs | 9862 |
| Obsolete RXNORM DFs | 59 |
| Editor-suppressed SCDs | 1675 |
| Editor-suppressed SBDs | 1348 |
| SAB=RXNORM NDCs | 230091 |
| Distinct SAB=RXNORM NDCs | 230091 |
Last Reviewed: July 13, 2017