May Release - 5/06/2019
This release of RxNorm is consistent with the 2019AA UMLS Metathesaurus release. For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.
Sources
The following sources with version names in bold have been updated since the previous RxNorm release:
| Source Name | SAB | Version |
|---|---|---|
| Vaccines Administered | CVX | CVX_2019_03_21 |
| DrugBank | DRUGBANK | DRUGBANK5.0_2019_04_04 |
| Gold Standard Drug Database | GS | GS_2019_03_29 |
| Multum MediSource Lexicon | MMSL | MMSL_2019_04_01 |
| Micromedex RED BOOK | MMX | MMX_2019_04_01 |
| Medical Subject Headings (MeSH) | MSH | MSH2019_2019_01_07 |
| FDA Structured Product Labels | MTHSPL | MTHSPL_2019_04_29 |
| FDB MedKnowledge (formerly NDDF Plus) | NDDF | NDDF_2019_03_27 |
| RxNorm normalized names and codes | RXNORM | RXNORM_19AA_190506F |
| Veterans Health Administration National Drug File | VANDF | VANDF_2019_03_31 |
The following sources have not been updated since the previous RxNorm release:
| Source Name | SAB | Version |
|---|---|---|
| Anatomical Therapeutic Chemical Classification System | ATC | ATC_2019 |
| CMS Formulary Reference File | MTHCMSFRF | MTHCMSFRF_2014 |
| US Edition of SNOMED CT (drug information) | SNOMEDCT_US | SNOMEDCT_US_2019_01_31 |
| USP Compendial Nomenclature | USP | USP_2018_12_10 |
*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact: medispan-support@wolterskluwer.com.
Data Changes
Qualitative Distinction
Qualitative Distinction modifiers allow flexibility in the RxNorm model to create new RXCUIs as needed. See the RxNorm Technical Documentation for more information about Qualitative Distinctions (QDs), which were first released in the August 2016 monthly release.
Here are the new concepts with QDs in the May 2019 release:
| RXCUI | TTY | String |
|---|---|---|
| 2123111 | SCD | NDA020503 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler |
| 746763 | SBD | NDA020503 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler [Proventil] |
| 2123076 | SCD | NDA020983 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler |
| 859088 | SBD | NDA020983 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler [Ventolin] |
| 801092 | SCD | NDA020983 60 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler |
| 801095 | SBD | NDA020983 60 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler [Ventolin] |
| 2123072 | SCD | NDA021457 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler |
| 745752 | SBD | NDA021457 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler [ProAir] |
| 2123194 | SCD | Pulmonary Hypertension tadalafil 20 MG Oral Tablet |
| 849866 | SBD | Pulmonary Hypertension tadalafil 20 MG Oral Tablet [Adcirca] |
| 2110455 | SBD | Pulmonary Hypertension tadalafil 20 MG Oral Tablet [Alyq] |
For each SCD or SBD with a QD, there is an associated attribute in RXNSAT with the attribute name (ATN) of 'RXN_QUALITATIVE_DISTINCTION'. The May release contains the following new attribute value (ATV) to match the QD strings found in the SCD and SBD normalized names:
- NDA020503
- NDA020983
- NDA021457
- Pulmonary Hypertension
NOTE: Multi-Ingredient Biologic Products and Naming in RxNorm
The National Library of Medicine (NLM) is aware that the biological product with multiple ingredients, Herceptin Hylecta, is currently misrepresented in RxNorm. The suffix is currently placed on one of the ingredients. However, after discussions with the U.S. Food & Drug Administration (FDA), NLM learned that the FDA’s intent is that the suffix is placed on the combination of ingredients.
- Current RxNorm interpretation: trastuzumab and hyaluronidase-oysk
- Correct interpretation: (trastuzumab and hyaluronidase)-oysk
The RxNorm team is collaborating with drug compendia, the National Council on Prescription Drug Programs (NCPDP), and the FDA to determine the best way to represent this information in electronic systems. Once a model is identified, NLM will work to modify the RxNorm data to represent this in a consistent manner with other drug information sources.
Data Counts
| Term Type or Attribute | Number |
|---|---|
| Active GPCKs | 390 |
| Active BPCKs | 487 |
| Active SCDs | 18371 |
| Active SBDs | 10342 |
| Active RXNORM MINs | 3818 |
| Active RXNORM INs | 12236 |
| Active RXNORM PINs | 2853 |
| Active RXNORM BNs | 5893 |
| Active RXNORM DFs | 118 |
| Obsolete GPCKs | 190 |
| Obsolete BPCKs | 163 |
| Obsolete SCDs | 16680 |
| Obsolete SBDs | 10901 |
| Obsolete RXNORM MINs | 0 |
| Obsolete RXNORM INs | 0 |
| Obsolete RXNORM PINs | 0 |
| Obsolete RXNORM BNs | 6202 |
| Obsolete RXNORM DFs | 60 |
| Editor-suppressed SCDs | 1756 |
| Editor-suppressed SBDs | 1454 |
| SAB=RXNORM NDCs | 256089 |
| Distinct SAB=RXNORM NDCs | 256089 |
Last Reviewed: May 6, 2019