December Release - 12/07/2020
For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.
Sources
The following sources with version names in bold have been updated since the previous RxNorm release:
| Source Name | SAB | Version |
|---|---|---|
| Vaccines Administered | CVX | CVX_2020_11_16 |
| DrugBank | DRUGBANK | DRUGBANK5.0_2020_10_29 |
| Gold Standard Drug Database | GS | GS_2020_11_17 |
| Multum MediSource Lexicon | MMSL | MMSL_2020_11_01 |
| Micromedex RED BOOK | MMX | MMX_2020_11_16 |
| Medical Subject Headings (MeSH) | MSH | MSH2021_2020_07_16 |
| FDA Structured Product Labels | MTHSPL | MTHSPL_2020_11_30 |
| FDB MedKnowledge (formerly NDDF Plus) | NDDF | NDDF_2020_11_18 |
| RxNorm normalized names and codes | RXNORM | RXNORM_20AA_201207F |
| Veterans Health Administration National Drug File | VANDF | VANDF_2020_10_31 |
The following sources have not been updated since the previous RxNorm release:
| Source Name | SAB | Version |
|---|---|---|
| Anatomical Therapeutic Chemical Classification System | ATC | ATC_2020 |
| CMS Formulary Reference File | MTHCMSFRF | MTHCMSFRF_2020 |
| US Edition of SNOMED CT (drug information) | SNOMEDCT_US | SNOMEDCT_US_2020_07_31 |
| USP Compendial Nomenclature | USP | USP_2020_02_06 |
*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact: medispan-support@wolterskluwer.com.
COVID-19 Vaccines
The RxNorm Content Team is closely monitoring the status of Coronavirus Disease 2019 (COVID-19) vaccines and COVID-19 related medications. When they are approved by the U.S. Food & Drug Administration (FDA), the RxNorm Content Team will add standardized names and codes as quickly as possible. However, no set timeframe is available. Get more COVID-19 information from the FDA: https://www.fda.gov/emergency-preparedness-and-response/counterterrorism-and-emerging-threats/coronavirus-disease-2019-covid-19.
Data Changes
REMINDER: New Casirivimab and Imdevimab SCDs
Casirivimab and imdevimab are monoclonal antibodies that are to be administered together for the treatment of COVID-19. Casirivimab and imdevimab are each available in two different vial sizes.
NOTE: Currently, we do not have a National Drug Code (NDC) for a packaged product of casirivimab and imdevimab together. Therefore, generic pack (GPCK) names are not available at this time.
Here are the new casirivimab Semantic Clinical Drug (SCD) names, RxNorm Concept Unique Identifier (RXCUI), and NDC:
- SCD: 11.1 ML casirivimab 120 MG/ML Injection
- RXCUI: 2465246
- NDC: 61755002401
- SCD: 2.5 ML casirivimab 120 MG/ML Injection
- RXCUI: 2465248
- NDC: 61755002601
Here are the new imdevimab SCD names, RXCUI, and NDC:
- SCD: 11.1 ML imdevimab 120 MG/ML Injection
- RXCUI: 2465253
- NDC: 61755002501
- SCD: 2.5 ML imdevimab 120 MG/ML Injection
- RXCUI: 2465255
- NDC: 61755002701
Get more information about Emergency Use Authorization (EUA) of casirivimab and imdevimab from the FDA:
- https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-monoclonal-antibodies-treatment-covid-19
- https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization
Get more information about RxNorm’s policy change on investigational drugs from NLM: https://www.nlm.nih.gov/pubs/techbull/ma20/ma20_rx_norm_investigational_drugs.html
UMLSAUI & UMLSCUI Attributes Deleted
The UMLSAUI and UMLSCUI were deleted from the release files, specifically RXNSAT.RRF, RXNDOC.RRF in the full monthly release, and RXNSAT.RRF in the Current Prescribable Content Monthly release. Users can obtain the UMLSAUI and UMLSCUI directly from the Metathesaurus if needed. Also, UMLS Metathesaurus data is no longer updated as of the November 2020 monthly release. See the RxNorm Release Notes 11/02/2020 for more information.
Data Counts
| Term Type or Attribute | Number |
|---|---|
| Active GPCKs | 430 |
| Active BPCKs | 516 |
| Active SCDs | 16864 |
| Active SBDs | 9416 |
| Active RXNORM MINs | 3735 |
| Active RXNORM INs | 13070 |
| Active RXNORM PINs | 3063 |
| Active RXNORM BNs | 5122 |
| Active RXNORM DFs | 121 |
| Obsolete GPCKs | 230 |
| Obsolete BPCKs | 197 |
| Obsolete SCDs | 18250 |
| Obsolete SBDs | 10723 |
| Obsolete RXNORM MINs | 0 |
| Obsolete RXNORM INs | 0 |
| Obsolete RXNORM PINs | 0 |
| Obsolete RXNORM BNs | 6100 |
| Obsolete RXNORM DFs | 63 |
| Editor-suppressed SCDs | 1792 |
| Editor-suppressed SBDs | 1479 |
| SAB=RXNORM NDCs | 247679 |
| Distinct SAB=RXNORM NDCs | 247679 |
Last Reviewed: December 7, 2020