Changing Explanations in Mind-Body Medicine is an undergraduate class resource that examines the exhibition “And there’s the humor of it” Shakespeare and the four humors for our understanding of how practicing physicians and medical scientists have, over a considerable period of time, typically explained disease and the factors which cause it. Looking selectively at Western medicine over its long history and in the most basic terms, it focuses on the recurrent ways in which biological (body-based) and psychological (mind- or emotion-based) explanations have been used to account for diseases of both the body and mind, and it challenges the common assumption that biological explanations are always better.