These notes accompanied the 1959 NLM exhibit that detailed the history of aspirin, from the drug’s roots as willow bark used in ancient times, to the distilling of key chemicals to make the aspirin pills that we are familiar with now. Aspirin’s formulation has gone largely unchanged since the exhibit opened in the 1950s. Today, aspirin is still a popular over the counter medication; however, we now know much more about its limits and potential.