Technical Notes - e1

Year-End Processing [corrected 1999/12/02] - e2

MeSH Coming Attractions - e3

Fees and New Format for Leasing NLM Databases in 2000 - e4

Scope Expands for PubMed and MEDLINE - e5

Data Changes Expected - e6

Hands On - e7

2000 Update Schedule for MEDLINE on PubMed and Internet Grateful Med [corrected 1999/12/02]

New in 2000 MeSH
The following changes and additions are of particular importance and interest for 2000:

• Nervous System Diseases (C10) were reorganized and the vocabulary was extensively revised to reflect current developments. There were 214 new headings added to the Nervous System Diseases (C10) tree and 24 terms were added to the Central Nervous System tree (A8). New terms in these two trees account for almost half of the new descriptors added this year.
• Symptoms and General Pathology, the C23 tree, was extensively modified with a number of new terms added. Many terms that are also in other trees were removed from this tree.
• GTP-Binding Proteins, in the D tree, were expanded with the addition of 16 specific proteins and many associated enzymes along with the rearrangement of closely related concepts.
• The Plants (B6) tree had 13 new descriptors added to identify plants of medicinal interest.
• The C21 tree, formerly called Injuries, Poisonings, and Occupational Diseases, has been renamed Disorders of Environmental Origin.

Statistical Summary of Changes to 2000 MeSH
The following table is a brief statistical summary of the changes made to the 2000 MeSH.

Publication Types and Subheadings
There were no new Publication Types or subheadings added or deleted for 2000. The only change is to the subheading "Drug Therapy" as shown below (the deleted words are italicized):

1999 scope note for "Drug Therapy":

Used with disease headings for the treatment of disease by the administration of drugs, chemicals, and antibiotics. For diet therapy and radiotherapy, use specific subheadings. Excludes immunotherapy and treatment with biologicals for which "therapy" is used.

2000 scope note for "Drug Therapy":

Used with disease headings for the treatment of disease by the administration of drugs, chemicals, and antibiotics. For diet therapy and radiotherapy, use specific subheadings. Excludes immunotherapy for which "therapy" is used.

Previously, treatment of a disease with biological factors and products which are treed in D24, required coordination of the disease with /therapy rather than /drug therapy. With the development of recombinant forms of these drugs, such as Interferons, it became more difficult for both indexers and searchers to recognize whether the substance being prescribed was a "drug" or a "biological product". Thus, we will routinely now coordinate all of these substances with the disease/drug therapy.

For comprehensive searching in PubMed, remember to use the broader subheading "/therapy" since PubMed automatically explodes subheadings and thus will retrive citations indexed using both definitions. For example, to search PubMed to find citations discussing BCG Vaccine (a D24 concept) and the treatment of tuberculosis use the search strategy:

bcg vaccine AND tuberculosis/therapy

If you wished to find citations indexed using one of the two scope notes then use the search strategy:

For citations indexed during or after the 2000 indexing year:

bcg vaccine AND tuberculosis/drug therapy

For citations indexed before the 2000 indexing year:

bcg vaccine AND tuberculosis/therapy [mh:noexp]

2000 MeSH terms for symptoms and related disorders

There are six symptoms for which MeSH has also provided a precoordinated disorder term. The symptoms are in both C10 (Nervous System Diseases) and in C23 (Symptoms and General Pathology), while the disorders are only in C10. In each case, the scope notes for the symptom reminds you that diseases which are characterized by persistence or recurrence of the symptom should be indexed and searched for as the precoordinated disorder.

New 2000 MeSH Headings
There were too many new descriptors added to the 2000 MeSH to list them all here. This article highlights new descriptors related to the nervous system, GTP-Binding proteins, plants, fungi, and bacteria. The complete lists of new and modified descriptors are available on the MeSH web site at http://www.nlm.nih.gov/mesh/filelist.html.

A8 (Nervous System)

Anterior Thalamic Nuclei

Basal Nucleus of Meynert

Diagonal Band of Broca

Entopeduncular Nucleus

Fornix (Brain)

Fourth Ventricle

Internal Capsule

Intralaminar Thalamic

Nuclei Islands of Calleja

Lateral Thalamic Nuclei

Lateral Ventricles

Mediodorsal Thalamic Nucleus

Metencephalon

Midline Thalamic Nuclei

Parahippocampal Gyrus

Posterior Horn Cells

Posterior Thalamic Nuclei

Pulvinar

Septum of Brain

Spinocerebellar Tracts

Subthalamic Nucleus

Subthalamus

Third Ventricle

Ventral Thalamic Nuclei

C10 (Nervous System Diseases)
The complete list of the 214 new terms added to this tree is available within the list of 552 new terms on the MeSH Web site at: http://www.nlm.nih.gov/mesh/filelist.html. Scroll down to New Headings with Scope Notes and click there.

(Various Branches of the D tree)

ADP-Ribosylation Factors

cdc42 GTP-Binding Protein

cdc42 GTP-Binding Protein, Yeast

Chimerin Proteins

Chimerin 1

EIF-2B

GTP Phosphohydrolase Activators

GTP Phosphohydrolase-Linked Elongation Factors

GTP Phosphohydrolases

GTP-Binding Protein Regulators

GTPase-Activating Proteins

Guanine Nucleotide Dissociation Inhibitors

Guanine Nucleotide Exchange Factors

Guanine Nucleotide-Releasing Factor 2

Heterotrimeric GTP-Binding Proteins

Monomeric GTP-Binding Proteins

Peptide Elongation Factor G

Peptide Elongation Factor 1

Peptide Elongation Factor 2

p120 GTPase Activating Protein

rab GTP-Binding Proteins

rab1 GTP-Binding Proteins

rab2 GTP-Binding Protein

rab3 GTP-Binding Proteins

rab3A GTP-Binding Protein

rab4 GTP-Binding Proteins

rab5 GTP-Binding Proteins

rac GTP-Binding Proteins

rac1 GTP-Binding Protein

ral GTP-Binding Proteins

ral Guanine Nucleotide Exchange Factor

ran GTP-Binding Protein

rap GTP-Binding Proteins

rap1 GTP-Binding Proteins

ras GTPase-Activating Proteins

RGS Proteins

rho GTP-Binding Proteins

rhoA GTP-Binding Protein

rhoB GTP-Binding Protein

B3 (Bacteria)

Afipia

alpha Proteobacteria

Alteromonas

Arcobacter

Azoarcus

Azorhizobium

Azorhizobium caulinodans

beta Proteobacteria

Buchnera

Cellvibrio

Comamonas

Comamonas acidovorans

Comamonas testosteroni

delta Proteobacteria

Ectothiorhodospira

Ectothiorhodospira halophila

Ectothiorhodospira shaposhnikovii

Edwardsiella

Edwardsiella ictaluri

Edwardsiella tarda

epsilon Proteobacteria

gamma Proteobacteria

Gluconobacter

Gluconobacter oxydans

Hafnia

Hafnia alvei

Halomonas

Hyphomicrobium

Lawsonia

Methylobacillus

Methylobacterium

Methylobacterium extorquens

Methylococcus

Methylococcus capsulatus

Methylomonas

Methylophilus

Methylophilus methylotrophus

Methylosinus

Methylosinus trichosporium

Morganella

Morganella morganii

Ochrobactrum anthropi

Oxalobacter formigenes

Pantoea

Photorhabdus

Proteobacteria

Rahnella

Rhodomicrobium vannielii

Shewanella

Shewanella putrefaciens

Sinorhizobium

Sphingomonas

Stenotrophomonas

Stenotrophomonas maltophilia

Stigmatella

Stigmatella aurantiaca

Taylorella equigenitalis

Thauera

Thiocapsa

Thiocapsa roseopersicina

Vitreoscilla

Wolbachia

Xanthobacter

Xenorhabdus

B5 (Algae and Fungi)

Reishi

Shiitake Mushrooms

Usnea

B6 (Plants)

Calendula

Cat's Claw

Chamomile

Comfrey

Echinacea

Equisetum

Feverfew

Ginger

Hypericum

Kava

Milk Thistle

Taxus

Vitex

--prepared by Jacque-Lynne Schulman

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