NLM Colloquia on Biomedical Data Science and
Computational Biology Research
NLM welcomes Timothy J. Petros, PhD, Tenure-Track Investigator for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), to present his lecture entitled “Mechanisms Regulating Fate and Maturation of Forebrain Inhibitory Interneurons” at our NLM Colloquia on Biomedical Data Science and Computational Biology Research. Please join us on December 11, 2024, at 11:00am ET in Room E1/E2 of the NIH Natcher Building (45) and online via NIH Videocast.
The NLM Colloquia is a series of scientific lectures featuring experts from across the bioinformatics community who present their research in the rapidly evolving fields of biomedical data science and computational biology research and discuss how it contributes to advancing biomedical discovery. This series is presented by NLM’s Division of Intramural Research, a premier hub of innovation for computational biology and biomedical data science.
Mechanisms Regulating Fate and Maturation of Forebrain Inhibitory Interneurons
Event Date: Wednesday, December 11, 2024
Time: 11:00am–12:00pm
Speaker: Timothy J. Petros, PhD
Location: NIH Natcher Building (45), Room E1/E2 and virtual via NIH Videocast
Abstract:
Proper brain function requires a balance between excitatory projection neurons and inhibitory interneurons, an incredibly diverse cell population with distinct transcriptomes, morphologies, connectivity, and electrophysiological properties. Abnormal interneuron development and function has been linked to the pathobiology of neurological and psychiatric disorders such as schizophrenia, autism, and epilepsy. Many genes implicated in these brain disorders are strongly enriched in neural progenitors—in some instances, specifically in developing interneurons. Understanding mechanisms that regulate interneuron fate, maturation, and function is critical to understand both normal development and disease etiologies.
Dr. Petros’ lab utilizes innovative, cutting-edge, and multifaceted approaches to characterize the gene regulatory mechanisms and transcriptional cascades that drive initial interneuron fate decisions during embryogenesis and how these processes go awry in neurodevelopmental disorders. Their recent development of an “Epigenome Atlas” of the embryonic mouse brain and follow-up studies explore how specific chromatin interactions and epigenetic processes regulate interneuron fate.
Speaker Bio:
Dr. Timothy Petros obtained his PhD from Columbia University, where he investigated the guidance factors that regulate retinal ganglion cell projections and explored the mechanisms that regulate interneuron differentiation. At New York University, he began to untangle the intrinsic genetic programs and extrinsic brain environment factors that direct interneuron diversity and maturation. His lab at NICHD lab utilizes innovative, cutting-edge, and multifaceted approaches to characterize the gene regulatory mechanisms and transcriptional cascades that drive initial interneuron fate decisions during embryogenesis and how these processes go awry in neurodevelopmental disorders.
How to Join:
NIH Natcher Building (45), Room E1/E2
This talk will be broadcast live: NIH Videocast
Interpreting services are available upon request. Individuals with disabilities who need reasonable accommodation to participate in this lecture should contact NLMColloquia@nih.gov or the Federal Relay (1-800-877-8339).
Questions during the presentation can be sent to: NLMColloquia@nih.gov.
Sponsored by:
Richard Scheuermann, PhD
Scientific Director, Division of Intramural Research, National Library of Medicine